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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: THOP1 All Species: 22.73
Human Site: S674 Identified Species: 50
UniProt: P52888 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52888 NP_003240.1 689 78840 S674 K Q D A F L L S K G L Q V G G
Chimpanzee Pan troglodytes XP_001163103 681 78041 A671 K R E P N Q K A F L M S R G L
Rhesus Macaque Macaca mulatta XP_001117760 648 74185 S635 K Q D A F L L S K G L Q V G D
Dog Lupus familis XP_533954 769 86949 S756 K Q D A F L L S K G L Q V D S
Cat Felis silvestris
Mouse Mus musculus Q8C1A5 687 78007 S674 K Q D A F L L S K G L Q V E G
Rat Rattus norvegicus P24155 687 78367 S674 K Q D A F L L S K G L Q V E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_424755 698 80358 A688 E R K P S Q R A F L L S K G L
Frog Xenopus laevis NP_001081384 685 78119 S671 K P E A F L Q S K G L A N V N
Zebra Danio Brachydanio rerio NP_001002355 686 77960 S671 K Q D A F L L S K G L T A D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P25375 712 81915 A703 G R E P S K D A F L K E L G L
Red Bread Mold Neurospora crassa Q7SDD5 805 91077 E784 E R L E G G G E K A M K L V G
Conservation
Percent
Protein Identity: 100 61.9 84.6 80.8 N.A. 88.9 88.6 N.A. N.A. 62.4 71.1 74.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 76.4 86.9 84.6 N.A. 93.4 93.1 N.A. N.A. 77.7 82.8 85.6 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 93.3 86.6 N.A. 93.3 93.3 N.A. N.A. 13.3 53.3 73.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 40 93.3 86.6 N.A. 93.3 93.3 N.A. N.A. 33.3 60 73.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 36.3 23.7
Protein Similarity: N.A. N.A. N.A. N.A. 53.9 41.2
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 40 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 64 0 0 0 28 0 10 0 10 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 55 0 0 0 10 0 0 0 0 0 0 19 10 % D
% Glu: 19 0 28 10 0 0 0 10 0 0 0 10 0 19 0 % E
% Phe: 0 0 0 0 64 0 0 0 28 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 10 10 10 0 0 64 0 0 0 46 37 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 73 0 10 0 0 10 10 0 73 0 10 10 10 0 0 % K
% Leu: 0 0 10 0 0 64 55 0 0 28 73 0 19 0 28 % L
% Met: 0 0 0 0 0 0 0 0 0 0 19 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 0 0 0 0 0 10 0 10 % N
% Pro: 0 10 0 28 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 55 0 0 0 19 10 0 0 0 0 46 0 0 0 % Q
% Arg: 0 37 0 0 0 0 10 0 0 0 0 0 10 0 0 % R
% Ser: 0 0 0 0 19 0 0 64 0 0 0 19 0 0 10 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 46 19 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _